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Hitchhiking under positive Darwinian selection.

J C Fay1, C I Wu

  • 1Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA.

Genetics
|July 6, 2000
PubMed
Summary

Positive selection drives linked genetic variation to high frequencies, a pattern detectable even with limited data. This hitchhiking effect is a unique signature of selection across various recombination rates.

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Area of Science:

  • Evolutionary genetics
  • Population genetics
  • Molecular evolution

Background:

  • Positive selection influences linked neutral genetic variation.
  • Recombination affects the extent of linked variation removal or fixation.
  • Hitchhiking is a key evolutionary process under positive selection.

Purpose of the Study:

  • To identify and quantify the impact of positive selection on linked neutral variation.
  • To develop a statistical method to detect hitchhiking.
  • To apply the developed method to empirical genetic data.

Main Methods:

  • Developed a statistic (H) to measure the excess of high-frequency derived variants.
  • Utilized deterministic and stochastic models of positive selection.
  • Analyzed published population genetic data from Drosophila.

Main Results:

  • An excess of high-frequency derived variants is a unique signature of hitchhiking.
  • The H statistic effectively detects hitchhiking even in regions with low variation or limited recombination.
  • Application to Drosophila data revealed an excess of high-frequency variants, indicating positive selection.

Conclusions:

  • The H test provides a robust method for inferring positive selection from population genetic data.
  • Hitchhiking significantly shapes patterns of genetic variation in natural populations.
  • Evidence of positive selection is widespread in Drosophila, as indicated by excess high-frequency variants.

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