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BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for

J S Thompson1, P Schneider, S L Kalled

  • 1Department of Molecular Genetics, Biogen, Incorporated, Cambridge, Massachusetts 02142, USA.

The Journal of Experimental Medicine
|July 6, 2000
PubMed

The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor-triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population.

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