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Anergic T cells as active regulators of the immune response
1Institute of Infectious Diseases and Immunology, Department of Immunology, Utrecht University, The Netherlands.
Human Immunology
|July 6, 2000
Abstract:
T cell anergy is one of the mechanisms leading to the establishment and maintenance of peripheral tolerance. Recent data from our and other laboratories indicate that anergic T cells are not functionally inert but in fact are capable of regulating the immune response in an active manner. In this review, we describe our viewpoint on how anergic self-reactive T cells could contribute to regulation of the immune response.