Insulin treatment with preprandial injections of regular insulin in middle-aged type 2 diabetic patients. A two years observational study
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1Department of Metabolic Diseases and Nutrition, Heinrich-Heine University Düsseldorf, Germany.
Aims:
To describe effectivity and safety variables in Type 2 diabetic patients on preprandial regular insulin therapy before each main meal (supplementary insulin therapy SIT) during an observational period.
Methods:
A group of 77 consecutive Type 2 diabetic patients in whom SIT was initiated at this department between January 1994 and March 1998 were subjected to a follow-up examination after a mean of two years during which time they were mainly cared for by their family physicians.
Results:
For 86 % patients (n =66) the continuation of SIT was documented; in 41 % of them (n =27) a bed time injection of NPH insulin was added in order to adequately control fasting glycaemia. HbA1c had fallen from 9.3 +/-1.8 to 7.4 +/-1.7 %; no episode of major hypoglycaemia occurred; there was no statistically significant increase in body weight.
Conclusions:
This observational study describes favourable intermediate outcome parameters of effectivity and safety for prandial regular insulin therapy of Type 2 diabetic patients, such as lowering of HbA1c without occurrence of major hypoglycaemia and without weight gain. Controlled trials are needed to confirm the encouraging results from this pilot study.
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