[The clinical laboratory characteristics of 104 cases of cryptococcal meningoencephalitis]
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Updated: Oct 15, 2026

Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid for the Detection of Central Nervous System Pathogens
Published on: April 17, 2026
1Divisão de Neuroinfectologia e Neuroepidemiologia, Universidade Federal da Bahia, Salvador, BA.
Abstract:
With the purpose of describing the clinical and laboratory characteristics of cryptococcus meningoencephalitis, we reviewed the records of 104 patients admitted with this diagnosis at Couto Maia Hospital, reference for patients with infectious diseases in Salvador-BA Northeastern Brazil, from 1972 to 1996. The patients' age varied from 8 months to 79 years. Sixty-four (61.5%) patients were male. The duration of the disease varied from 2 to 150 days, average 27.7 days. The most common signs and symptoms were headache (92.7%), fever (84.4%) and neck stiffness (83.2%). The cell number in cerebrospinal fluid was greater than 4/mm > or = in 95.8% of the patients with lymphocyte predominance in 86.3% of the cases. The lethality rate was 42.7%.
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