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[RIII mefloquine resistance in children with falciparum malaria in Manaus, AM, Brazil]
E Noronha1, M G Alecrim, G A Romero
1Núcleo de Medicina Tropical e Nutrição, Universidade de Brasília, Brasília, DF, 70919-970, Brasil. tropical@unb.br
Insights
Mefloquine resistance occurred in 5.9% of children treated for falciparum malaria in Manaus, Brazil. This highlights the need to monitor mefloquine resistance in pediatric malaria cases.
Area of Science:
- Tropical Medicine
- Infectious Diseases
- Parasitology
Abstract:
We report the occurrence of resistance to mefloquine 20mg/day in 51 children with falciparum malaria treated, at reference center of Manaus, Brazil, from October to December 1997. All children were evaluated at day 3, 5, 7, 14, 21, 28 and 35 of treatment. Clinical and parasitological cure criteria were adopted. The incidence of RIII mefloquine resistance was 5.9% (IC 95% 1.5-17.2). The cure/resistance proportion was 20:1 and cure/severity was 62:1. These findings suggest the importance of mefloquine resistance within this group of children.