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Related Experiment Videos

Multiple sclerosis and antecedent infections: a case-control study.

R A Marrie1, C Wolfson, M C Sturkenboom

  • 1Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

Neurology
|July 6, 2000
PubMed
Summary
This summary is machine-generated.

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A history of infectious mononucleosis (IM) significantly increases the risk of developing multiple sclerosis (MS). Respiratory tract infections (RTI) may also precede MS onset, suggesting infections play a role in MS etiology.

Area of Science:

  • Neurology
  • Epidemiology
  • Infectious Diseases

Background:

  • The exact cause of multiple sclerosis (MS) is unknown.
  • Infections are suspected as potential triggers for MS.
  • Previous studies on respiratory tract infections (RTI) and infectious mononucleosis (IM) in MS have yielded conflicting results.

Purpose of the Study:

  • To investigate if respiratory tract infections (RTI) are more common before MS onset.
  • To determine the association between a history of infectious mononucleosis (IM) and the risk of developing MS.

Main Methods:

  • A case-control study was conducted using the UK General Practice Research Database.
  • 225 MS patients and 900 matched controls were analyzed.
  • Computerized records were used to compare RTI rates and IM history before the MS index date.

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Main Results:

  • An increased frequency of RTI was linked to a higher risk of MS across all studied periods.
  • Individuals with a history of IM had over five times the risk of developing MS (OR = 5.5).

Conclusions:

  • A history of infectious mononucleosis (IM) is associated with an increased risk of subsequent multiple sclerosis (MS).
  • Respiratory tract infections (RTI) might act as a trigger for MS disease onset.