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Stability and sterility of recombinant tissue plasminogen activator at -30 degrees C

J T Wiernikowski, M Crowther, C M Clase

    Lancet (London, England)
    |July 6, 2000
    PubMed

    Abstract:

    We assessed whether frozen recombinant tissue plasminogen activator (rt-PA) remains stable and sterile for up to 22 weeks at -30 degrees C. Our findings confirm that rt-PA is a cost-effective alternative to urokinase for restoring patency to occluded central venous catheters.

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