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Related Experiment Videos

M6P/IGF2R imprinting evolution in mammals.

J K Killian1, J C Byrd, J V Jirtle

  • 1Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Molecular Cell
|July 6, 2000
PubMed
Summary

Genomic imprinting in mammals evolved independently of invasive placentation. M6P/IGF2R imprinting in marsupials demonstrates that complex fetal development is not required for imprinting to arise.

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Area of Science:

  • Genomics
  • Evolutionary Biology
  • Developmental Biology

Background:

  • Genomic imprinting, a phenomenon where genes are expressed in a parent-of-origin-specific manner, has primarily been studied in eutherian mammals.
  • Its association with intrauterine development suggests a role for invasive placentation in imprinting evolution.

Purpose of the Study:

  • To investigate the evolutionary origins of genomic imprinting in mammals.
  • To determine if M6P/IGF2R imprinting is conserved across different mammalian clades.
  • To explore the relationship between imprinting, IGF2R function, and placental development.

Main Methods:

  • Comparative genomic analysis of M6P/IGF2R in monotremes and marsupials.
  • Investigating M6P/IGF2R imprinting status in the opossum.

Related Experiment Videos

  • Analyzing methylation patterns of the M6P/IGF2R gene, specifically the CpG island in intron 2.

    • Main Results:

    • M6P/IGF2R is not imprinted in monotremes and does not bind IGF2.
    • M6P/IGF2R exhibits imprinting in the opossum (a marsupial).
    • The opossum's imprinted M6P/IGF2R lacks the CpG island in intron 2, previously thought essential for imprinting control.

    Conclusions:

    • Invasive placentation and advanced fetal growth are not prerequisites for the evolution of genomic imprinting.
    • The findings suggest that M6P/IGF2R imprinting and its role in binding IGF2 may have evolved independently in marsupials and eutherians, or exclusively within a more recent mammalian clade.
    • This challenges previous hypotheses linking imprinting evolution solely to complex intrauterine development.