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CD4(+) lymphocyte-mediated suppression of cytomegalovirus expression in human astrocytes
1Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA.
Clinical and Diagnostic Laboratory Immunology
|July 7, 2000
Abstract:
Cytomegalovirus-stimulated CD4(+) lymphocytes from seropositive but not seronegative donors suppressed viral gene expression in primary human astrocytes. This suppressive activity was mediated through soluble factors. These findings suggest that CD4(+) lymphocytes play a role in defense of the brain against cytomegalovirus.