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Updated: Jul 24, 2026

A General Method for Evaluating Incubation of Sucrose Craving in Rats
Published on: November 4, 2011
The pharmacokinetics and metabolism of sucralose in the dog
S G Wood1, B A John, D R Hawkins
1Huntingdon Research Centre Ltd, Huntingdon, Cambs PE18 6ES, UK.
Abstract:
The pharmacokinetics and metabolism of sucralose were investigated in dogs following intravenous or oral administration. Oral doses of (14)C-sucralose were rapidly absorbed, although there was some variation in the extent of absorption (range 18-48% of the dose). After intravenous or oral administration, radioactivity excreted in the urine was associated mainly with unchanged sucralose. One urinary metabolite was detected after both intravenous and oral doses and was identified by mass spectrometry as a glucuronic acid conjugate of sucralose. This metabolite accounted for about 15-20% of the intravenous dose but for only about 2-8% of the oral dose.
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