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Effect of Helicobacter pylori eradication on malignant transformation of gastric adenoma
1First Department of Internal Medicine, Gunma University School of Medicine, Japan.
Background:
A nonrandomized trial of Helicobacter pylori eradication was conducted in patients with endoscopically diagnosed gastric adenoma to determine the long-term effect of antimicrobial treatment on progression of the adenoma.
Methods:
Of 64 patients with an endoscopically diagnosed gastric adenoma and H pylori infection, 32 were treated with omeprazole and antibiotics to eradicate the infection, and 32 were not.
Results:
During 2 years of follow-up, 4 (12.5%) of the 32 patients in the untreated group developed an early stage, intestinal-type gastric cancer, whereas no gastric cancer was found in the 32 patients in the treated group.
Conclusion:
H Pylori eradication may inhibit progression of gastric adenoma to carcinoma.