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Radiation-associated xanthomatous meningioma in a child
Abstract:
Radiation-associated meningioma in a child is rare. We report a case of xanthomatous meningioma, a rare subtype even in the adult population, which occurred in a 10-year-old boy who had undergone irradiation therapy for ependymoma at the age of 2 years. Histological examination of the tumor revealed a mixture of meningothelial cells and abundant foamy xanthomatous cells, with no apparent atypical cellular features. Xanthomatous meningioma associated with therapeutic high-dose irradiation in a child has not yet been documented. Immunohistochemical studies and the clinical course are evaluated with a review of the literature.
Insights
A rare xanthomatous meningioma developed in a 10-year-old boy years after radiation therapy for ependymoma. This case highlights a unique association between childhood radiation and this specific meningioma subtype.
Area of Science:
- Pediatric neuro-oncology
- Neurosurgery
- Radiation oncology
Background:
- Radiation-associated meningiomas are uncommon, particularly in pediatric patients.
- Xanthomatous meningioma is a rare subtype, even in adults.
- Childhood brain tumors often require radiation therapy, posing long-term risks.
Observation:
- A 10-year-old boy developed a xanthomatous meningioma.
- The patient had received high-dose irradiation therapy at age 2 for an ependymoma.
- Histological examination showed meningothelial and foamy xanthomatous cells without atypia.
Findings:
- This is the first documented case of xanthomatous meningioma associated with therapeutic irradiation in a child.
- Immunohistochemical studies were performed to characterize the tumor.
- The tumor exhibited a unique histological composition of xanthomatous cells.
Implications:
- This case expands the understanding of potential long-term effects of pediatric radiation therapy.
- It suggests a possible link between high-dose irradiation and the development of xanthomatous meningiomas in children.
- Further research is warranted to investigate the mechanisms and incidence of radiation-induced xanthomatous meningiomas.