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High risk mammographic parenchymal patterns and diet: a case-control study.
1Department of Public Health and Primary Care, Worts Causeway, Cambridge, UK.
British Journal of Cancer
|July 7, 2000
Summary
High intake of protein, carbohydrates, and meat is linked to increased mammographic density, a breast cancer risk factor. Diet, particularly macronutrients, influences breast tissue morphology and potentially cancer risk.
Area of Science:
- Nutritional Epidemiology
- Breast Cancer Research
- Radiology
Background:
- Mammographic parenchymal patterns are indicators of breast cancer risk.
- Dietary factors are hypothesized to influence mammographic patterns.
Purpose of the Study:
- To investigate the association between dietary intake and mammographic parenchymal patterns.
- To identify specific food and nutrient influences on breast tissue morphology.
Main Methods:
- A case-control study involving 200 high-risk and 200 low-risk mammographic patterns.
- Utilized the Wolfe classification system for mammogram evaluation.
- Collected dietary data via 7-day food diaries and analyzed nutrient intake.
Main Results:
- Higher intake of total protein and carbohydrates correlated with increased odds of high-risk mammographic patterns (OR=2.00 and OR=1.93).
- Total meat intake showed a strong positive association with high-risk patterns in post-menopausal women (OR=2.50).
- No significant association was found for fat intake or vitamin intake with mammographic patterns.
Conclusions:
- Dietary protein, carbohydrates, and meat intake may influence breast cancer risk by altering breast tissue morphology.
- Mammographic parenchymal patterns can serve as biomarkers for dietary effects on breast cancer risk.
- Fat and vitamin intake do not appear to affect mammographic density.