Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive function in aged ovariectomized female rhesus monkeys.

A Lacreuse1, J G Herndon, M B Moss

  • 1Division of Neuroscience, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322, USA. alacreu@rmy.emory.edu

Behavioral Neuroscience
|July 7, 2000
PubMed
Summary

Ovariectomy in aged monkeys did not worsen visual memory decline but may protect against age-related spatial memory deficits. Estrogen deprivation effects on cognition require further study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex Differences in Cognitive Flexibility and Resting Brain Networks in Middle-Aged Marmosets.

eNeuro·2019
Same author

Oestradiol modulation of cognition in adult female marmosets (Callithrix jacchus).

Journal of neuroendocrinology·2014
Same author

Hematology and serum chemistry values of sooty mangabeys (Cercocebus atys): comparison with rhesus monkeys.

Journal of medical primatology·2013
Same author

An interactive procedure for extracting features of the brain from magnetic resonance images: the lobes.

Human brain mapping·2010
Same author

The role of exercise on L-arginine nitric oxide pathway in chronic heart failure.

The open biochemistry journal·2009
Same author

The genomic response of the ipsilateral and contralateral cortex to stroke in aged rats.

Journal of cellular and molecular medicine·2008

Area of Science:

  • Neuroscience
  • Primate Cognition
  • Aging Research

Background:

  • Age-related cognitive decline is a significant concern.
  • The role of estrogen in cognitive function and aging is complex.
  • Ovariectomy (OVX) removes the primary source of estrogen.

Purpose of the Study:

  • To investigate if early-life ovariectomy exacerbates age-related cognitive decline in aged monkeys.
  • To assess the long-term effects of estrogen deprivation on different types of memory.

Main Methods:

  • Comparison of cognitive performance in ovariectomized aged monkeys (OVX-Aged) versus age-matched controls with intact ovaries (INT-Aged) and young controls (INT-Young).
  • Evaluation across tasks assessing visual recognition memory, object and spatial memory, and executive function.

Related Experiment Videos

Main Results:

  • OVX-Aged monkeys showed marginal impairment in a delayed visual recognition task (600s delay) compared to INT-Aged.
  • OVX-Aged monkeys performed significantly better than INT-Aged controls on a spatial delayed recognition task.
  • Evidence for exacerbated age-related decline in visual recognition memory due to estrogenic deprivation was not strongly supported.

Conclusions:

  • Long-term ovariectomy may offer protection against the development of spatial memory deficits associated with aging.
  • Further research is needed to fully understand the impact of prolonged estrogenic deprivation on age-related cognitive decline, particularly visual recognition memory.