Related Experiment Videos
Poststroke dementia : clinical features and risk factors
R Barba1, S Martínez-Espinosa, E Rodríguez-García
1Servicio de Medicina Interna, Hospital de Alcorcón, Madrid, Spain. rbarba@fhalcorcon.es
Stroke
|July 8, 2000
Summary
Post-stroke dementia (PSD) affects 30% of stroke survivors. Key risk factors include older age, prior mental decline, atrial fibrillation, and stroke severity.
Area of Science:
- Neurology
- Gerontology
- Public Health
Background:
- Post-stroke dementia (PSD) is a significant complication following cerebrovascular events.
- Identifying risk factors for PSD is crucial for patient management and prevention strategies.
Purpose of the Study:
- To investigate potential risk factors for post-stroke dementia (PSD) in a cohort of 251 unselected stroke patients.
- To examine associations between PSD and factors related to cerebrovascular disease and degenerative dementia.
Main Methods:
- Prospective application of a standard protocol including clinical, functional, cognitive, and laboratory assessments.
- Utilized Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria for PSD and NINDS-AIREN for vascular dementia.
- Included genetic analysis (apolipoprotein E, angiotensin-converting enzyme) and neuropsychological testing.
Main Results:
- Dementia was diagnosed in 30% of patients at 3-month follow-up; 10% had pre-existing dementia.
- Dementia risk was associated with older age (OR 1.1), previous nephropathy (OR 6.1), atrial fibrillation (OR 4.4), low Canadian Neurological Scale score (OR 0.5), and prior mental decline (OR 1.2).
- Risk factors remained consistent when excluding patients with prior dementia or hemorrhagic stroke.
Conclusions:
- Dementia is a common outcome after both ischemic and hemorrhagic strokes.
- Independent predictors of PSD include advanced age, history of nephropathy, atrial fibrillation, pre-stroke cognitive decline, and stroke severity.