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NMR imaging investigations of drug delivery devices using a flow-through USP dissolution apparatus
C A Fyfe1, H Grondey, A I Blazek-Welsh
1Department of Chemistry, University of British Columbia, V6T 1Z1, Vancouver, BC, Canada.
Abstract:
A system for performing NMR imaging experiments on drug delivery devices within a flow-through dissolution apparatus, USP Apparatus 4, has been developed. The system was used to image the physical changes that occur in solid dosage forms during dissolution in the flow-through apparatus. Simultaneous cumulative drug release measurements were also made. The NMR images obtained under these conditions and the drug release data provide a better understanding of the processes involved in the release of drugs from drug delivery systems based on diffusion, dissolution and osmosis mechanisms.