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Updated: Jul 26, 2026

Imaging Centrosomes in Fly Testes
Published on: September 21, 2013
Spindle pole body duplication: a model for centrosome duplication?
1Wellcome/CRC Institute of Cancer and Developmental Biology, Cambridge, UK. ira20@mole.bio.cam.ac.uk
Abstract:
The yeast spindle pole body (SPB) is the functional equivalent of the centrosome and forms the two poles of the mitotic spindle. Before mitosis, both SPBs and centrosomes are present as single copies and must be duplicated to form the bipolar spindle. SPB components have been identified using a combination of biochemistry and genetics, and their role during SPB duplication has been analysed using temperature-sensitive mutants. In this article, we describe structural aspects of SPB duplication and their possible relationship to centrosome duplication.
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