Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

x ray crystallography.

M S Smyth1, J H Martin

  • 1Department of Biochemistry, University of Leicester, UK.

Molecular Pathology : MP
|July 8, 2000
PubMed
Summary
This summary is machine-generated.

X-ray crystallography is a key technique for determining protein structures, aiding research across biological sciences. This method provides crucial insights for drug design and understanding molecular interactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unravelling the speed-going relationship: A proof of concept study from British turf flat and jump race meetings.

Journal of equine veterinary science·2024
Same author

A Comparison of Several Assay Procedures to Detect Penicillin Residues in Milk <sup>1</sup>.

Journal of food protection·2019
Same author

Comparing subjective and objective evaluation of show jumping competition and warm-up arena surfaces.

Veterinary journal (London, England : 1997)·2017
Same author

Persistence of DNA adducts, hypermutation and acquisition of cellular resistance to alkylating agents in glioblastoma.

Cancer biology & therapy·2017
Same author

Motor cortex and spinal cord neuromodulation promote corticospinal tract axonal outgrowth and motor recovery after cervical contusion spinal cord injury.

Experimental neurology·2017
Same author

Mannan oligosaccharide prepartum supplementation: effects on dairy cow colostrum quality and quantity.

Animal : an international journal of animal bioscience·2017
Same journal

Development of molecular methods for the identification of aspergillus and emerging moulds in paraffin wax embedded tissue sections.

Molecular pathology : MP·2003
Same journal

Tempero-spatial dissociation between the expression of Fas and apoptosis after coronary occlusion.

Molecular pathology : MP·2003
Same journal

Inverse correlation between high level expression of cyclin E and proliferation index in transitional cell carcinoma of the bladder.

Molecular pathology : MP·2003
Same journal

Nuclear beta catenin as a potential prognostic and diagnostic marker in patients with colorectal cancer from Hong Kong.

Molecular pathology : MP·2003
Same journal

Increased cyclin D1 expression in cancer of the ampulla of Vater: relevance to nuclear beta catenin accumulation and k-ras gene mutation.

Molecular pathology : MP·2003
Same journal

Expression of the cell cycle regulatory proteins p34cdc2, p21waf1, and p53 in node negative invasive ductal breast carcinoma.

Molecular pathology : MP·2003
See all related articles

Area of Science:

  • Biochemistry
  • Structural Biology
  • Biophysics

Background:

  • X-ray crystallography is the primary method for determining the three-dimensional structures of proteins and biological macromolecules.
  • Structural information is increasingly vital for advancing research in diverse biological disciplines.
  • Determining protein structures offers a focused approach for future scientific investigations.

Purpose of the Study:

  • To highlight the significance of X-ray crystallography in modern biological sciences.
  • To demonstrate the broad applicability of crystallography in studying complex biological systems.
  • To showcase the impact of structural data on various research areas.

Main Methods:

  • Utilizing X-ray crystallography for the structural determination of proteins.

Related Experiment Videos

  • Applying the technique to complex systems including viruses, immune complexes, and protein-nucleic acid complexes.

    • Main Results:

    • X-ray crystallography provides essential structural information for proteins and macromolecules.
    • The technique's application has expanded to include viruses, immune complexes, and protein-nucleic acid complexes.
    • Structural data derived from crystallography has clarified numerous research questions.

    Conclusions:

    • X-ray crystallography is indispensable for understanding biological macromolecules.
    • The technique's versatility supports advancements in structure-based drug design, mutagenesis, enzyme mechanisms, and protein-ligand interactions.
    • Structural insights from crystallography drive innovation and deeper understanding in biological research.