Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin-like effects of vanadium: basic and clinical implications.

I Goldwaser1, D Gefel, E Gershonov

  • 1Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel.

Journal of Inorganic Biochemistry
|July 8, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tuftsin-phosphorylcholine (TPC) equally effective to methylprednisolone in ameliorating lupus nephritis in a mice model.

Clinical and experimental immunology·2018
Same author

Novel therapeutic compound tuftsin-phosphorylcholine attenuates collagen-induced arthritis.

Clinical and experimental immunology·2015
Same author

From antioxidant chelators to site-activated multi-target chelators targeting hypoxia inducing factor, beta-amyloid, acetylcholinesterase and monoamine oxidase A/B.

Mini reviews in medicinal chemistry·2012
Same author

Insulin-like effects of tungstate and molybdate: mediation through insulin receptor independent pathways.

Endocrine·2010
Same author

Lactogenic hormones rapidly activate p21( ras )/mitogen-activated protein kinase in Nb2-11C rat lymphoma cells.

Endocrine·2010
Same author

Engineering prolonged-acting prodrugs employing an albumin-binding probe that undergoes slow hydrolysis at physiological conditions.

Journal of controlled release : official journal of the Controlled Release Society·2009
Same journal

Bimetallic Anilinopyridinate ruthenium(II,III) complexes: Synthesis, characterisation, and in vitro selective cytotoxicity towards MCF-7 breast cancer cells.

Journal of inorganic biochemistry·2026
Same journal

Ca<sup>2+</sup> effects on manganese oxidation by the bacterial multicopper oxidase complex Mnx.

Journal of inorganic biochemistry·2026
Same journal

The chemistry of the cobalt corrinoids - Recent advances and emerging themes. Part 3. Cobalamins and health.

Journal of inorganic biochemistry·2026
Same journal

PIKfyve-specific Pt(II)-based targeted drug conjugate in treatment of ovarian cancer through multi-mode actions.

Journal of inorganic biochemistry·2026
Same journal

From PET to targeted radionuclide therapy in the Brain: The emerging role of radiometal-based platforms.

Journal of inorganic biochemistry·2026
Same journal

The chemistry of the cobalt corrinoids - Recent advances and emerging themes. Part 2. The biochemistry, microbiology, and ecology.

Journal of inorganic biochemistry·2026
See all related articles

Vanadium exhibits insulin-like effects, showing promise for diabetes treatment by normalizing blood glucose. New organically chelated vanadium compounds offer reduced toxicity and enhanced potency.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Trace Element Research

Background:

  • Mammalian cells contain vanadium, a trace element with no established physiological role.
  • Vanadate inhibits Na+,K+-ATPase; vanadium mimics insulin's metabolic effects.
  • Vanadium acts independently of the insulin receptor in key metabolic tissues.

Purpose of the Study:

  • To investigate the antidiabetic potential of vanadium.
  • To explore vanadium's insulin-mimetic properties in diabetic models.
  • To review novel organically chelated vanadium compounds for improved therapeutic outcomes.

Main Methods:

  • Review of studies on vanadium's effects on Na+,K+-ATPase and insulin signaling.
  • Analysis of vanadium's efficacy in streptozotocin-induced diabetic rats and type II diabetic rodents.

Related Experiment Videos

  • Evaluation of organically chelated vanadium compounds for potency and toxicity.

    • Main Results:

    • Vanadium normalizes blood glucose in diabetic rodents and corrects hyperglycemia-related deficiencies.
    • Therapeutic effects observed in type II diabetic rodents resistant to insulin.
    • Organically chelated vanadium compounds demonstrate higher potency and lower toxicity than vanadium salts.

    Conclusions:

    • Vanadium holds significant therapeutic potential for diabetes management.
    • Overcoming vanadium toxicity is crucial for clinical application.
    • Novel organically chelated vanadium compounds represent a promising advancement in vanadium-based antidiabetic therapy.