Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clozapine augmentation: safety and efficacy.

S A Chong1, G Remington

  • 1Woodbridge Hospital and Institute of Mental Health, Singapore.

Schizophrenia Bulletin
|July 8, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Examining psychological distress among youth in Singapore: Insights from the National Youth Mental Health Study.

Asian journal of psychiatry·2025
Same author

Tardive dyskinesia versus tardive syndrome. What is in a name?

Parkinsonism & related disorders·2025
Same author

Adherence to clozapine vs. other antipsychotics in schizophrenia.

Acta psychiatrica Scandinavica·2020
Same author

Tracking the mental health of a nation: prevalence and correlates of mental disorders in the second Singapore mental health study.

Epidemiology and psychiatric sciences·2019
Same author

The Singaporean public beliefs about the causes of mental illness: results from a multi-ethnic population-based study.

Epidemiology and psychiatric sciences·2017
Same author

Association between recognition and help-seeking preferences and stigma towards people with mental illness.

Epidemiology and psychiatric sciences·2016
Same journal

The Effect of Semaglutide on Antipsychotic-Induced Weight Gain and Other Metabolic Parameters, among a Cohort of Inpatients.

Schizophrenia bulletin·2026
Same journal

Comparing Apples to Oranges Obscures Tortoises Beating Hares: The Relationship Between Rate of Antipsychotic Tapering and Relapse.

Schizophrenia bulletin·2026
Same journal

Beyond the Need for Speed: D2 Receptor Affinity Predicts Relapse after Antipsychotic Tapering in First Episode Psychosis.

Schizophrenia bulletin·2026
Same journal

Correction to: The Mini-CAARMS: Development and Validation of a Short Version of the Comprehensive Assessment of AT Risk Mental States to Facilitate Preventive Psychiatry.

Schizophrenia bulletin·2026
Same journal

Longitudinal Impact of Birthweight and its Polygenic Risk Score on Glucose and Antipsychotic-Induced Weight Gain in First Episode Psychosis.

Schizophrenia bulletin·2026
Same journal

The Key to Clozapine Mystery May Lie in its Shape.

Schizophrenia bulletin·2026
See all related articles

Clozapine augmentation strategies for refractory schizophrenia are reviewed. While combinations with benzodiazepines, valproate, or lithium pose risks, no combination is entirely unsafe, though more controlled data are needed.

Area of Science:

  • Pharmacology
  • Psychiatry
  • Clinical Medicine

Background:

  • Clozapine is effective for refractory schizophrenia, schizoaffective, and bipolar disorders.
  • A significant portion of patients remain unresponsive to clozapine monotherapy.
  • Augmentation with other somatic treatments is a strategy for non-responsive patients.

Purpose of the Study:

  • To review the efficacy and safety of clozapine combined with other somatic treatments.
  • To synthesize available data on clozapine augmentation strategies.
  • To highlight the need for systematic review of combination therapies.

Main Methods:

  • Manual and computerized (Medline) literature search from 1978 to March 1998.
  • Inclusion of 70 English-language articles.

Related Experiment Videos

  • Analysis of case reports, case series, and limited controlled studies.

    • Main Results:

    • Greatest risk of adverse effects observed with clozapine combined with benzodiazepines, valproate, or lithium.
    • No currently evaluated combination was found to be absolutely unsafe.
    • Data suggest potential efficacy for several augmentation strategies, but controlled data are scarce.

    Conclusions:

    • Combination therapies with clozapine are frequently used in clinical practice.
    • Empirical data supporting these combinations are limited.
    • Systematic review of the benefits and risks of clozapine augmentation is necessary.