[Stimulation and differentiation of lymphocytes after injuries]

In seven patients who underwent major trauma, stimulation of lymphocytes with phytohaemagglutinin, pokeweed mitogen, and concanavalin A was investigated. Furthermore the differentiation of lymphocytes into T- and B-cells was studied. The synthesis rates of DNA (3H-thymidine incorporation) and RNA (3H-uridine incorporation) are qualitatively depressed at different time intervals. The T- and B-cell relation is altered in favor of the B-lymphocytes.