Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Caloric restriction and genomic stability.

J J Raffoul1, Z Guo, A Soofi

  • 1Department of Nutrition & Food Science, Wayne State University, Detroit, Michigan 48202, USA.

The Journal of Nutrition, Health & Aging
|July 8, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does Exposure to Static Magnetic Fields Generated by Magnetic Resonance Imaging Scanners Raise Safety Problems for Personnel?

Journal of biomedical physics & engineering·2018
Same author

Developmental potential of vitrified holstein cattle embryos fertilized in vitro with sex-sorted sperm.

Journal of dairy science·2006
Same author

Adipogenic human adenovirus-36 reduces leptin expression and secretion and increases glucose uptake by fat cells.

International journal of obesity (2005)·2006
Same author

Viral mRNA expression but not DNA replication is required for lipogenic effect of human adenovirus Ad-36 in preadipocytes.

International journal of obesity (2005)·2006
Same author

Association of asymptomatic oral candidal carriage, oral candidiasis and CD4 lymphocyte count in HIV-positive patients in China.

Oral diseases·2006
Same author

Interpretation of the ultrasonic effect on induction time during BaSO4 homogeneous nucleation by a cluster coagulation model.

Journal of colloid and interface science·2005
Same journal

Corrigendum to "Probable respiratory sarcopenia trajectories and the risk of incident chronic diseases: findings from the China health and retirement longitudinal study" [J Nutr Health Aging, 30 (2026) 100903].

The journal of nutrition, health & aging·2026
Same journal

Associations of sarcopenia with the risk of incident respiratory disease and the role of inflammation and metabolism: a prospective cohort study.

The journal of nutrition, health & aging·2026
Same journal

Corrigendum to "Association of serum 25-hydroxyvitamin D with the risk of depression in individuals with prediabetes and diabetes: A prospective cohort study" [J Nutr Health Aging, 29 (2025) 100556].

The journal of nutrition, health & aging·2026
Same journal

Association between living arrangements in early old age and subsequent trajectories of protein intake among older adults in China.

The journal of nutrition, health & aging·2026
Same journal

Associations of adiponectin, leptin, and the adiponectin-to-leptin ratio with sarcopenia in older adults with cardiovascular-kidney-metabolic syndrome.

The journal of nutrition, health & aging·2026
Same journal

Association of artificial sweeteners intake and risk of CKD: a prospective cohort study.

The journal of nutrition, health & aging·2026
See all related articles

Caloric restriction (CR) extends lifespan in rodents by potentially reducing DNA damage and mutations. Further research is needed to confirm the role of DNA repair pathways in CR

Area of Science:

  • Aging research
  • Genetics
  • Molecular biology

Background:

  • Caloric restriction (CR) consistently increases lifespan and reduces age-related diseases in rodents.
  • CR's anti-aging effects are hypothesized to involve reduced DNA damage and mutations.
  • Genome integrity is crucial for cellular and organismal health.

Purpose of the Study:

  • To review proposed mechanisms of DNA damage and repair in relation to CR.
  • To explore current research on CR's life-extending mechanisms.
  • To identify the role of DNA repair pathways in CR's anti-aging effects.

Main Methods:

  • Review of existing literature on CR, aging, and DNA damage/repair.
  • Analysis of correlative evidence linking CR, DNA damage, and lifespan.

Related Experiment Videos

  • Discussion of the need for advanced assays and genetic models.

    • Main Results:

    • CR is correlated with decreased DNA damage and mutation accumulation.
    • CR is associated with increased DNA repair capacity in rodents.
    • Current evidence is primarily correlative, necessitating further investigation.

    Conclusions:

    • The link between CR, DNA damage reduction, and longevity requires further experimental validation.
    • Investigating specific DNA repair pathways and enzymes is crucial.
    • Understanding these mechanisms could unlock CR's life-prolonging effects.