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Synthesis and cytotoxic activity of thiazolyl indolequinones
C J Moody1, J R Roffey, E Swann
1School of Chemistry, University of Exeter, Devon, UK. c.j.moody@exeter.ac.uk
Anti-Cancer Drugs
|July 8, 2000
Abstract:
A number of thiazolyl indolequinones have been prepared and evaluated for their antitumor properties. The compounds were synthesized from the appropriate indole, building up the thiazole ring using the Hantzsch reaction. Cytotoxic activity was determined in the human breast cancer SKBr3 cell line. Selected compounds were also studied in human lung carcinoma A549 and PV9 cell lines. In addition, some compounds were evaluated for their possible bioreductive action by determining their cytotoxicity towards V79 Chinese hamster lung fibroblasts in air and under anaerobic (hypoxic) conditions.