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Related Experiment Videos

Ruled by waves? Intracellular and intercellular calcium signalling.

J Røttingen1, J G Iversen

  • 1Laboratory of Intracellular Signalling, Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Acta Physiologica Scandinavica
|July 25, 2000
PubMed
Summary
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Calcium ions (Ca2+) act as crucial intracellular signals, coordinating cellular functions. Recent research highlights their role as intercellular signals, synchronizing physiological responses across tissues and organs.

Area of Science:

  • Physiology
  • Cell Biology
  • Biochemistry

Background:

  • Calcium ions (Ca2+) have long been recognized as critical intracellular signals, mediating processes like muscle contraction and neurotransmission.
  • The discovery of calcium as a second messenger revolutionized cell signaling research.
  • Advancements in measurement techniques have significantly expanded our understanding of intracellular calcium signaling pathways.

Purpose of the Study:

  • To provide an overview of intracellular calcium signaling mechanisms.
  • To review emerging evidence on the role of calcium as an intercellular signal.
  • To explore the physiological implications of calcium-mediated intercellular communication.

Main Methods:

  • Literature review of intracellular and intercellular calcium signaling.

Related Experiment Videos

  • Analysis of recent data on calcium's role in cell-to-cell communication.
  • Discussion of physiological relevance and synchronization of responses.

    • Main Results:

    • Intracellular calcium signaling involves complex cellular machinery.
    • Calcium acts as an intercellular signal, coordinating cell populations and organs via gap junctions.
    • This intercellular signaling is crucial for synchronizing physiological responses.

    Conclusions:

    • Calcium's role extends beyond intracellular functions to critical intercellular communication.
    • Intercellular calcium signaling, particularly via gap junctions, is vital for coordinating physiological processes.
    • Understanding calcium's dual role is essential for comprehending complex physiological regulation.