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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

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Published on: February 16, 2015

Adoptive Immunotherapy and Interleukin-2 Following High-dose Therapy: A Potential Approach to Reduce Residual Tumor

Zorsky1

  • 1Bone Marrow Transplant Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.

Cancer Control : Journal of the Moffitt Cancer Center
|May 1, 1994
PubMed

Immune modulation and adoptive immunotherapy are being investigated as an additional cancer treatment modality. The influence of immunologic reactions, manifested as graft-vs-host disease (GVHD), has clearly been demonstrated in patients undergoing allogeneic bone marrow transplantation. More recently, adoptive immunotherapy by infusion of donor peripheral blood leukocyte products to recipients at relapse has shown benefit. As the immune system regenerates after high-dose therapy and stem cell transplantation, it is possible that we may be able to enhance an immune response against tumor cells. Trials are underway to evaluate the effect of interleukin-2 (IL-2) given early after transplantation to produce this effect.

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