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SRBC rosette formation as a human T lymphocyte marker.

M Jondal

    Scandinavian Journal of Immunology
    |June 1, 1976
    PubMed
    Summary

    Researchers developed a method using sheep red blood cells to identify and isolate human T lymphocytes via rosette formation and sedimentation. This technique aids in T cell research.

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    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Human T lymphocytes play a crucial role in immune responses.
    • Accurate identification and isolation of T cells are essential for immunological studies.

    Purpose of the Study:

    • To describe a novel technique for identifying and separating human T lymphocytes.
    • To establish a method utilizing sheep red blood cells for T cell isolation.

    Main Methods:

    • The study employed rosette formation, using sheep red blood cells as a marker for human T lymphocytes.
    • Separation of T cells was achieved through rosette sedimentation.

    Main Results:

    • The described technique successfully utilizes rosette formation to identify T lymphocytes.
    • Rosette sedimentation effectively separates the marked T cells from other blood components.

    Conclusions:

    • This method provides a reliable way to isolate human T lymphocytes.
    • The technique is valuable for immunological research requiring pure T cell populations.

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