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Updated: Oct 15, 2026

Real-time Live Imaging of T-cell Signaling Complex Formation
Published on: June 23, 2013
Role of cAMP-dependent signal transduction in the control of T lymphocyte activation
1Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, 614081, Russia. conf@ecology.psu.ru
Abstract:
The role of cAMP in the regulation of antigen-dependent differentiation of T cells is discussed with consideration of the molecular mechanisms of cAMP effects. Characteristics of activation signal in various T lymphocyte subpopulations determining differential sensitivity to cAMP are reviewed. Specific attention is given to the involvement of the cAMP-dependent messenger system in the formation of the spectrum of secreted cytokines because their level and ratio determine the type of immune response.
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