Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Reactions

Allergic Reactions

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

Antiasthma Drugs: Leukotriene Modifiers

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Are biomarkers associated with sensitivity to physical activity?

European journal of pain (London, England)·2023

Same author

Mass Coral Reef Bleaching: A Recent Outcome of Increased El Niño Activity?

Ecology letters·2021

Same author

Chronotherapy of Non-Steroidal Anti-Inflammatory Drugs May Enhance Postoperative Recovery.

Scientific reports·2020

Same author

Benchmarking nurse outcomes in Australian Magnet® hospitals: cross-sectional survey.

BMC nursing·2019

Same author

Characterization of a novel capsaicin/heat ongoing pain model.

European journal of pain (London, England)·2017

Same author

Model-based reconstruction of an epidemic using multiple datasets: understanding influenza A/H1N1 pandemic dynamics in Israel.

Journal of the Royal Society, Interface·2016

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Published on: January 8, 2020

Medilan: a hypoallergenic lanolin for emollient therapy.

¹Dentistry and Dermatology Group, Guy's and St Thomas' Hospital Trust, London.

British Journal of Nursing (Mark Allen Publishing)

|July 11, 2000

Summary

Medilan, an ultra-purified lanolin, is hypoallergenic and causes minimal skin sensitization. It hydrates and soothes dry skin, making it ideal for eczema treatments.

Area of Science:

Dermatology
Cosmetic Science

Background:

Lanolin possesses emollient properties, historically used for skin care.
Recent perceptions have unfairly linked lanolin to significant skin sensitization.
Medilan represents a medical-grade, ultra-purified form of lanolin.

Purpose of the Study:

To evaluate the sensitization potential of Medilan, a purified lanolin.
To assess the skin hydration and penetration capabilities of Medilan.
To determine the suitability of Medilan in treating dry skin conditions like eczema.

Main Methods:

Clinical assessment of sensitization reactions to Medilan.
Measurement of skin hydration and stratum corneum water content.
Evaluation of Medilan's efficacy in emollient formulations.

More Related Videos

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Related Experiment Videos

Last Updated: Jun 25, 2026

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Published on: January 8, 2020

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Main Results:

Medilan demonstrated a very low rate of skin sensitization, approaching zero.
Medilan exhibits occlusive properties and enhances water retention in the stratum corneum.
The purified lanolin showed significant soothing and hydrating effects.

Conclusions:

Medilan's hypoallergenic nature and demonstrated efficacy make it a safe and valuable ingredient.
It is highly suitable for emollient preparations targeting eczema and other dry skin conditions.
Medilan effectively counters the negative reputation of traditional lanolin regarding sensitization.