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Synthesis and biological properties of new 1beta-methylcarbapenems having tetrazolothioether moiety
1Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, South Korea.
Bioorganic & Medicinal Chemistry Letters
|July 11, 2000
Abstract:
The synthesis and biological activities of a series of new 1beta-methylcarbapenems 1a-l having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanced pharmacokinetics compared with imipenem and meropenem.