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Synthesis and structure-activity relationships of novel fungal chitin synthase inhibitors
K Masubuchi1, M Taniguchi, I Umeda
1Department of Chemistry, Nippon Roche Research Center, Kamakura, Kanagawa, Japan.
Bioorganic & Medicinal Chemistry Letters
|July 11, 2000
Abstract:
A novel Candida albicans chitin synthase 1 (CaChs1) inhibitor, RO-41-0986 (1) was discovered by random screening. Systematic modification led to the identification of a highly potent CaChs1 inhibitor, RO-09-3024 (2), having strong antifungal activity against Candida spp. in vitro.