Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Statistical issues in tumor marker studies.

T F Pajak¹, G M Clark, D J Sargent

¹American College of Radiology, Philadelphia, PA 19107, USA.

Archives of Pathology & Laboratory Medicine

|July 11, 2000

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prognostic value of primary tumour resection in synchronous metastatic colorectal cancer: Individual patient data analysis of first-line randomised trials from the ARCAD database.

European journal of cancer (Oxford, England : 1990)·2018

Same author

Statistical controversies in clinical research: basket trials, umbrella trials, and other master protocols: a review and examples.

Annals of oncology : official journal of the European Society for Medical Oncology·2017

Same author

HaploSNP affinities and linkage map positions illuminate subgenome composition in the octoploid, cultivated strawberry (Fragaria×ananassa).

Plant science : an international journal of experimental plant biology·2015

Same author

Mapping QTL associated with Verticillium dahliae resistance in the cultivated strawberry (Fragaria × ananassa).

Horticulture research·2015

Same author

Comment on: 'evaluation of chemoresponse assays as predictive markers'.

British journal of cancer·2015

Same author

Survival following early-stage colon cancer: an ACCENT-based comparison of patients versus a matched international general population†.

Annals of oncology : official journal of the European Society for Medical Oncology·2015

Statistical considerations are crucial for accurate tumor marker studies. Addressing issues like statistical significance, power, and missing data ensures reliable prognostic marker interpretation and application.

Area of Science:

Biostatistics
Oncology
Biomarker Research

Background:

Tumor marker studies often face statistical challenges complicating result interpretation.
This article addresses key statistical issues in designing, conducting, and analyzing these studies.

Purpose of the Study:

To emphasize the critical role of statistical significance, risk ratios, statistical power, reproducibility, multiple testing, confirmatory studies, and missing data in prognostic marker study design.
To guide researchers in overcoming common statistical hurdles in tumor marker research.

Main Methods:

The article provides practical suggestions for improving marker study conduct.
Key recommendations include ensuring adequate sample size and standardizing assay methods.
Emphasis is placed on complete reporting of results and statistical analysis methods.

Related Experiment Videos

Main Results:

Implementing these statistical best practices can enhance the reliability and interpretability of tumor marker study findings.
Improved study design and execution lead to more robust conclusions.

Conclusions:

Effective tumor marker studies require collaboration between clinicians, laboratory scientists, and statisticians.
This interdisciplinary approach is essential for statistically sound studies and prioritizing markers, especially with limited resources.