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Updated: Aug 14, 2026
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Derivation of T Cells In Vitro from Mouse Embryonic Stem Cells
Published on: October 14, 2014
Stepwise specification of lymphocyte developmental lineages
1Division of Biology, California Institute of Technology, Pasadena 91125, USA. evroth@its.caltech.edu
Current Opinion in Genetics & Development
|July 13, 2000
Abstract:
B and T lymphocytes differentiate from multipotent precursors through distinct specification and commitment steps. New findings on the unique role of Pax5 in B-lineage commitment, dichotomous action of Notch signaling in B versus T cell development, and the gene expression changes comprising T-lineage specification and commitment now illuminate this process.
