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Diastolic biomechanics in normal infants utilizing MRI tissue tagging
M A Fogel1, P M Weinberg, A Hubbard
1Division of Pediatric Cardiology, Department of Pediatrics, The University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. fogel@email.chop.edu
Circulation
|July 13, 2000
Summary
Infant diastolic function is not uniform. Lateral walls show the most strain, while septal walls have minimal motion. Apical walls exhibit the greatest rotation, aiding in understanding infant heart disease.
Area of Science:
- Pediatric Cardiology
- Biomedical Engineering
- Cardiac Physiology
Background:
- Current understanding of infant diastolic function relies heavily on flow and pressure data.
- Limited information exists regarding regional diastolic strain and wall motion in infants.
Purpose of the Study:
- To investigate regional diastolic strain and wall motion in normal infants using magnetic resonance imaging.
- To establish normative data for infant diastolic biomechanics.
Main Methods:
- Magnetic resonance tissue tagging was employed in 11 healthy infants.
- Analysis included tracking diastolic motion and finite strain analysis to assess regional rotation, radial displacement, and circumferential (E2) and radial (E1) strains.
Main Results:
- Circumferential lengthening strains (E2) were significantly higher in the lateral walls, while radial thinning strains (E1) were uniform across regions.
- Septal walls demonstrated significantly less radial motion compared to other regions.
- Apical walls exhibited the greatest clockwise rotation, with regional variations in rotational direction observed at the atrioventricular valve level.
Conclusions:
- Infant diastolic biomechanics are heterogeneous, with distinct regional differences in strain and motion.
- Lateral walls are most influenced by strain, septal walls by radial motion, and apical walls by rotation.
- These findings provide crucial normative data for diagnosing diastolic dysfunction in infants, particularly those with congenital heart disease.
