Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Refractory celiac disease.

B M Ryan1, D Kelleher

  • 1Department of Gastroenterology and Clinical Medicine, St. James's Hospital and Trinity College, Dublin, Ireland.

Gastroenterology
|July 13, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dilated ducts with or without raised LFTs.

Irish medical journal·2025
Same author

Screening for undiagnosed pancreatic exocrine insufficiency (PEI) in a cohort of diabetic patients using faecal elastase testing and PEI scoring system.

Acta diabetologica·2024
Same author

Clinical Outcome of Patients with Raised Intraepithelial Lymphocytes with Normal Villous Architecture on Duodenal Biopsy.

Digestion·2017
Same author

KRT81 miR-SNP rs3660 is associated with risk and survival of NSCLC.

Annals of oncology : official journal of the European Society for Medical Oncology·2015
Same author

Articulating the value of health research.

QJM : monthly journal of the Association of Physicians·2014
Same author

Reforming the EU environment for clinical trials: what are the challenges?

QJM : monthly journal of the Association of Physicians·2013
Same journal

How important is fiber in the Crohn's disease story?

Gastroenterology·2026
Same journal

Reply to "Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy".

Gastroenterology·2026
Same journal

Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy.

Gastroenterology·2026
Same journal

A High-Risk Impaction: To Scope or to Stent First?

Gastroenterology·2026
Same journal

Epithelial FOXP3 orchestrates O-glycosylated IL-6 secretion to drive pancreatic fibrocarcinogenesis.

Gastroenterology·2026
Same journal

Reply to "Methodological Considerations on Neonatal Metabolomics and Future Inflammatory Bowel Disease".

Gastroenterology·2026
See all related articles

Refractory sprue, a gluten-resistant enteropathy, is often misdiagnosed. New research indicates it may be autoimmune enteropathy or cryptic intestinal T-cell lymphoma, requiring specific diagnostic tests for better treatment.

Area of Science:

  • Gastroenterology
  • Immunology
  • Oncology

Background:

  • Celiac disease is a gluten-sensitive enteropathy with villous atrophy reversible by gluten withdrawal.
  • Refractory sprue presents as celiac-like enteropathy resistant to a gluten-free diet.
  • It is a diagnosis of exclusion, requiring elimination of other enteropathy causes.

Purpose of the Study:

  • To investigate the diverse underlying causes of refractory sprue.
  • To differentiate between autoimmune enteropathy and cryptic intestinal T-cell lymphoma in refractory sprue patients.
  • To improve diagnostic strategies and therapeutic approaches for refractory sprue.

Main Methods:

  • Review of recent evidence on refractory sprue.
  • Identification of diagnostic markers for autoimmune enteropathy (antienterocyte antibodies).

Related Experiment Videos

  • Analysis of intraepithelial lymphocytes for monoclonal populations indicative of lymphoma (T-cell receptor studies, monoclonal antibody studies).

    • Main Results:

    • Refractory sprue is a heterogeneous condition.
    • A subset of patients exhibit adult-onset autoimmune enteropathy with antienterocyte antibodies.
    • A significant group presents with cryptic intestinal T-cell lymphoma, characterized by abnormal monoclonal intraepithelial lymphocytes.

    Conclusions:

    • Patients with refractory sprue should be screened for antienterocyte antibodies and undergo T-cell receptor and monoclonal antibody studies.
    • These tests can identify autoimmune enteropathy and cryptic T-cell lymphoma.
    • Early recognition of malignancy is crucial for developing targeted chemotherapeutic regimens.