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Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)
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Inhibition of azoxymethane-induced colon cancer by orange juice

Y Miyagi1, A S Om, K M Chee

  • 1Michigan State University, East Lansing 48824-1224, USA.

Nutrition and Cancer
|July 13, 2000
PubMed

Insights

Orange juice consumption significantly reduced colon cancer incidence in rats by 22%. This protective effect is linked to compounds like hesperidin, potentially offering chemopreventive benefits against colon tumors.

Area of Science:

  • Nutritional Science
  • Cancer Research
  • Gastroenterology

Background:

  • Hesperidin, a flavanone glycoside in orange juice, is known to inhibit colon carcinogenesis.
  • Previous studies indicated that double-strength orange juice delays chemically induced mammary cancer in rats.

Purpose of the Study:

  • To investigate the chemopreventive effects of single-strength, pasteurized orange juice on azoxymethane (AOM)-induced colon cancer in male Fischer 344 rats.

Main Methods:

  • Colon cancer was initiated in rats using azoxymethane (AOM) injections.
  • The experimental group (n=30) consumed orange juice instead of water for 28 weeks post-initiation.
  • Tumor incidence and histological analyses were performed.

Main Results:

  • Feeding orange juice resulted in a 22% reduction in colon tumor incidence (p < 0.05).
  • This reduction correlated with decreased labeling index and proliferation zone in the colonic mucosa.

Conclusions:

  • Single-strength, pasteurized orange juice demonstrates chemopreventive potential against colon tumorigenesis.
  • Hesperidin, other flavonoids, and limonoid glucosides in orange juice may contribute to this protective effect.

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