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Related Experiment Videos

Mefloquine concentration profiles during prophylactic dose regimens.

H Kollaritsch1, J Karbwang, G Wiedermann

  • 1Institute of Specific Prophylaxis and Tropical Medicine, University of Vienna, Austria. herwig.kollaritsch@univie.ac.at

Wiener Klinische Wochenschrift
|July 13, 2000
PubMed
Summary

Mefloquine hydrochloride prophylaxis achieved protective blood concentrations in all subjects. However, women experienced higher drug levels and more side effects, suggesting a need for dose adjustments in female malaria prevention.

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Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Tropical Medicine

Background:

  • Mefloquine hydrochloride is a common malaria prophylactic.
  • Understanding its pharmacokinetics in healthy adults is crucial for effective dosing.

Purpose of the Study:

  • To investigate the pharmacokinetics of mefloquine hydrochloride in healthy Caucasian adults.
  • To compare drug concentrations and tolerability between male and female subjects.

Main Methods:

  • 12 healthy adults (6 males, 6 females) received prophylactic mefloquine doses over 28 days.
  • Plasma concentrations (Cmin ss, Cmax ss, AUCd 0-35) were measured.
  • Adverse reactions were recorded.

Main Results:

  • All subjects reached protective mefloquine plasma concentrations after the third dose.

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  • Female subjects exhibited significantly higher Cmin ss, Cmax ss, and AUCd 0-35 compared to males.
  • Females reported more frequent adverse reactions, including headache, anorexia, insomnia, and vertigo.

    • Conclusions:

    • Higher mefloquine concentrations in females, likely due to lower body weight and volume of distribution, correlate with increased adverse events.
    • The findings suggest a potential need for adjusted prophylactic mefloquine dosing regimens for females.