Convergent synthesis of ribonuclease L-active 2',5'-oligoadenylate-peptide nucleic acids
1Section on Biomedical Chemistry, Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive antd Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0805, USA.
Bioorganic & Medicinal Chemistry Letters
|July 13, 2000
Abstract:
2-5A was conjugated to N-(2-aminoethyl)-glycyl PNA by periodate oxidization, followed by coupling with amino-derivatized PNA and final cyanoborohydride reduction. An adduct of 2-5A pentamer with tetrameric thymine PNA activated RNase L with the same potency as earlier versions of 2-5A-PNA or 2-5A-DNA.
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