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Synthesis and cytotoxic activity of acetogenin analogues
S Rodier1, Y Le Huérou, B Renoux
1Laboratoire de Synthèse et Réactivité des Substances Naturelles, Université de Poitiers et CNRS, France.
Bioorganic & Medicinal Chemistry Letters
|July 13, 2000
Abstract:
A set of 16 new simplified analogues of acetogenins has been designed based on: (i) the replacement of the bis THF moiety of these natural products by an ethylene glycol bis ether unit; (ii) the introduction of different lipophilic side chains (alkyl, aryl, dialkylamino, O-cholesteryl); (iii) the presence of the same terminal isolactone. In vitro cytotoxic activity against L1210 leukemia is reported.