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Related Experiment Videos

GH and bone--experimental and clinical studies.

O G Isaksson1, C Ohlsson, B A Bengtsson

  • 1Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, University of Göteborg, Sweden. olle.isaksson@medic.gn.se

Endocrine Journal
|July 13, 2000
PubMed
Summary
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Growth hormone (GH) treatment in adults with GH deficiency (GHD) initially increases bone resorption, then bone formation, leading to increased bone mass after 12-18 months. This biphasic model requires further validation in individuals with normal GH secretion.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Metabolic Research

Background:

  • Growth hormone (GH) plays a crucial role in bone metabolism, influencing both osteoblasts and locally produced insulin-like growth factor-I (IGF-I).
  • GH deficiency (GHD) is associated with reduced bone mass in humans and animals.
  • GH administration has shown positive effects on bone mass and strength in animal models and GHD patients.

Purpose of the Study:

  • To investigate the effects of GH on bone metabolism in adults with GHD.
  • To explore the proposed
  • Biphasic model
  • of GH action on bone remodeling.

Main Methods:

  • Review and synthesis of clinical studies on GH treatment in GHD adults.
  • Analysis of the temporal effects of GH on bone resorption and formation.

Related Experiment Videos

Main Results:

  • GH treatment in GHD adults stimulates both bone resorption and bone formation.
  • A biphasic effect is observed: initial bone loss followed by net bone mass increase.
  • The transition point occurs around six months, with significant bone mass gain typically seen after 12-18 months.

Conclusions:

  • The
  • Biphasic model
  • describes the dual action of GH on bone remodeling in GHD adults.
  • GH treatment can effectively increase bone mass in GHD adults over time.
  • The applicability of this biphasic model to individuals with normal GH secretion requires further investigation.