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Related Experiment Videos

Serotonin, stress and corticoids.

F Chaouloff1

  • 1NeuroGénétique and Stress, INSERM U471, Institut F. Magendie, Bordeaux, France. francis.chaouloff@bordeaux.inserm.fr

Journal of Psychopharmacology (Oxford, England)
|July 13, 2000
PubMed
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Stress significantly impacts serotonin (5-HT) neurotransmission in brain regions controlling fear and anxiety. Environmental factors and genetics influence these stress-induced changes in 5-HT systems.

Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Stress Research

Background:

  • Serotonergic transmission shows stressor- and brain region-specific responses to aversive stimuli.
  • The interplay between stress, corticoids, and the hypothalamo-pituitary-adrenal axis in modulating serotonergic systems is complex.

Purpose of the Study:

  • To review the effects of acute and chronic stressors on serotonin release, reuptake, levels, and receptors.
  • To examine the role of corticoids and the HPA axis in stress-induced alterations of serotonergic neurotransmission in key brain areas.
  • To explore the specificity of serotonergic responses to stress and their role in coping mechanisms.

Main Methods:

  • Literature review of studies on acute and chronic stress.
  • Analysis of effects on serotonin (5-HT) release, reuptake, extracellular levels, and receptor function.

Related Experiment Videos

  • Examination of data from brain regions including the dorsal and median raphe nuclei, frontal cortex, amygdala, and hippocampus.
  • Inclusion of studies investigating corticoid impacts and HPA axis involvement.

    • Main Results:

    • Stress demonstrably alters serotonergic transmission, partly mediated by corticoids.
    • Heterogeneous results indicate that the specificity of serotonergic responses to stress remains unclear.
    • Environmental factors and early life experiences may influence 5-HT sensitivity to stress.

    Conclusions:

    • Stress impacts serotonergic transmission, with corticoids playing a significant role.
    • Further research is needed to clarify the specificity of stressor effects on 5-HT systems.
    • Considering environmental and genetic factors is crucial for understanding stress effects on 5-HT neurotransmission and coping.