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Pyridoxine therapy in a patient with severe hydrazine sulfate toxicity
1Intensive Care Unit, Whangarei Hospital, New Zealand.
Objective:
To report hydrazine sulfate as a cause of severe encephalopathy and to report its response to high-dose pyridoxine therapy.
Design:
Case report.
Setting:
An adult six-bed medical/surgical intensive care unit of a general hospital.
Patient:
One patient who developed severe encephalopathy after hydrazine sulfate.
Intervention:
5 g i.v. pyridoxine.
Measurements And Main Results:
After 180 mg/day for 2 wks followed by 360 mg/day of hydrazine sulfate ingestion, our patient suffered severe encephalopathy. He received mechanical ventilation with attendant supportive measures and high-dose pyridoxine. The patient's encephalopathy resolved 24 hrs after receiving pyridoxine.
Conclusion:
Severe encephalopathy could result from hydrazine sulfate toxicity. High-dose pyridoxine is an effective treatment to reverse this encephalopathy.