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A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13
A J Muller1, A K Teresky, A J Levine
1DuPont Pharmaceuticals, Glenolden, PA 19036; and The Rockefeller University, New York, NY 10021, USA.
Abstract:
Inbred 129 strain mice are predisposed to developing male germ cell tumors (GCTs) of the testes. The inherent genetic defects that underlie male GCT susceptibility in the 129 mouse strain are unknown. GCT incidence is increased in 129 strain males that lack functional p53 protein, and we have used this finding to facilitate the generation of panels of GCT-bearing intercross and backcross mice for genetic mapping analysis. A 129 strain locus, designated pgct1, that segregates with the male GCT phenotype has been identified on chromosome 13 near D13Mit188. This region of murine chromosome 13 may be syntenic to a portion of human chromosome 5q that is implicated in male GCT susceptibility in humans.