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Polyaromatic Scavenger Reagents (PAHSR): A New Methodology for Rapid Purification in Solution-Phase Combinatorial
1Department of Chemistry, Parke-Davis Pharmaceutical Research, A Division of Warner-Lambert, 2800 Plymouth Road, Ann Arbor, Michigan 48105.
Organic Letters
|July 13, 2000
Abstract:
A new method of purification of solution-phase combinatorial libraries has been developed. Development of a chemically inert polyaromatic anchor with a reactive "scavenger reagent" (PAHSR) allows unreacted reagents and impurities to be removed from a reaction by absorption of the PAHSR to charcoal and simple filtration.