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Cleavage of N ',N '-dialkylhydrazides with PhI(OH)OTs
1Chemical Process Research and Development, 1500-91-201, Pharmacia and Upjohn, Kalamazoo, Michigan 49001, USA.
Organic Letters
|July 13, 2000
Abstract:
N',N'-Dimethylhydrazides are efficiently cleaved to give the carboxylic acid upon treatment with PhI(OH)OTs in water or water/CH(2)Cl(2) mixtures. The reaction occurs with the evolution of a gas.