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Pax4 represses pancreatic glucagon gene expression

H V Petersen1, M C Jørgensen, F G Andersen

  • 1Department of Developmental Biology, Hagedorn Research Institute, Niels Steensensvej 6, Gentofte, DK-2820, Denmark.

Molecular Cell Biology Research Communications : MCBRC
|July 13, 2000
PubMed
Summary

Paired box 4 (Pax4) transcription factor completely inhibits glucagon gene expression in rat cells. Pax4 also actively represses insulin gene transcription, independent of Pax6, highlighting its role in pancreatic endocrine cell development.

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