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Related Concept Videos

Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through interaction...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
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Updated: Jul 16, 2026

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
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Infantile convulsions with mild gastroenteritis.

T Abe1, M Kobayashi, K Araki

  • 1Department of Pediatrics, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan. htabe@med.teikyo-u.ac.jp

Brain & Development
|July 13, 2000
PubMed
Summary

New molecular techniques detect rotavirus and small round structured virus (SRSV) in patients with gastroenteritis and seizure symptoms. Further research is needed to understand how these viruses cause benign convulsions.

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Area of Science:

  • Virology
  • Pediatric Neurology
  • Infectious Diseases

Background:

  • Gastroenteritis viruses, including rotavirus and small round structured virus (SRSV), are increasingly detected in patients presenting with clinical symptoms resembling infantile benign convulsions.
  • Molecular genetic techniques have enhanced the detection of these viruses in various biological samples such as cerebrospinal fluid, stools, and throat swabs.

Purpose of the Study:

  • To review recent virological and clinical studies investigating the association between gastroenteritis viruses and seizures.
  • To explore the potential mechanisms by which viruses like rotavirus and SRSV may induce benign convulsions in infants.

Main Methods:

  • Review of existing literature on virological and clinical studies.
  • Analysis of diagnostic findings from cerebrospinal fluid, stools, and throat swabs.
  • Examination of clinical presentations of gastroenteritis with accompanying seizures.

Main Results:

  • Detection of rotavirus and SRSV in patients with gastroenteritis and seizure symptoms using advanced molecular methods.
  • Identification of clinical similarities between viral infections and benign convulsions.

Conclusions:

  • Viral infections, particularly rotavirus and SRSV, are implicated in cases of gastroenteritis accompanied by seizure-like symptoms.
  • The precise mechanisms linking these viral infections to benign convulsions require further elucidation through ongoing research.