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[Solid cell nests and thyroid pathologies. Retrospective study of 1,390 thyroids].

V Martin1, L Martin, G Viennet

  • 1Laboratoire d'Histologie, CNRS UPRESA 6025, Faculté de Médecine et de Pharmacie, 2, place Saint-Jacques, 25030 Besançon Cedex.

Annales De Pathologie
|July 13, 2000
PubMed
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Solid Cell Nests (SCN) in the thyroid are not linked to age or thyroid disorders. These nests contain neuroendocrine and thyroglobulin cells, supporting the ultimobranchial remnant theory for their origin.

Area of Science:

  • Endocrinology
  • Surgical Pathology
  • Developmental Biology

Background:

  • Solid Cell Nests (SCN) are thyroid structures with debated origins, previously thought to be embryonic remnants or squamous metaplasia.
  • Their cellular composition and developmental linkage remain incompletely understood.

Purpose of the Study:

  • To investigate the prevalence and cellular composition of Solid Cell Nests (SCN) in human thyroid glands.
  • To evaluate the association of SCN with age, thyroid disorders, and sex.
  • To assess the potential origin of SCN from ultimobranchial remnants.

Main Methods:

  • Retrospective analysis of 1,390 thyroidectomy specimens.
  • Histopathological examination to identify and quantify SCN.
  • Immunohistochemical staining for neuroendocrine markers (calcitonin, CGRP, chromogranin A) and thyroglobulin.

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Main Results:

  • SCN were identified in 9.7% of thyroids, with a higher prevalence in men (16%) than women (8%).
  • SCN prevalence increased with the number of sections examined.
  • No statistical correlation was found between SCN presence and patient age or thyroid disorders.
  • Neuroendocrine cells were present in 38% of SCN, and thyroglobulin cells in 78.3%.

Conclusions:

  • The findings support the ultimobranchial remnant theory for the origin of SCN, rather than squamous metaplasia.
  • The cellular composition of SCN, including neuroendocrine and thyroglobulin-producing cells, aligns with this developmental origin.
  • SCN may represent a potential origin for rare thyroid carcinomas, such as mixed medullary and follicular carcinoma or mucoepidermoid carcinoma.