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Related Experiment Videos

Effects of corticosteroid therapy on human monocyte function.

J J Rinehart, A L Sagone, S P Balcerzak

    The New England Journal of Medicine
    |January 30, 1975
    PubMed
    Summary

    High-dose prednisone therapy significantly impairs monocyte bactericidal and fungicidal activity, potentially increasing infection risk. Immune function returned to normal 48 hours after treatment cessation.

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    Area of Science:

    • Immunology
    • Pharmacology
    • Cell Biology

    Background:

    • High-dose corticosteroid therapy is known to affect immune function.
    • Cellular defense mechanisms may be compromised by corticosteroid treatment.
    • Understanding the impact on human monocyte function is crucial for managing corticosteroid-associated risks.

    Purpose of the Study:

    • To investigate the effects of high-dose prednisone on human monocyte function.
    • To assess the impact on bactericidal and fungicidal activities of monocytes.
    • To determine if other monocyte functions are affected by prednisone therapy.

    Main Methods:

    • Fifteen healthy volunteers received a three-day course of prednisone (50 mg every 12 hours).
    • Monocyte function was assessed before, during, and after prednisone therapy.

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  • Key functions evaluated included killing of Staphylococcus aureus and Candida tropicalis, phagocytosis, chemotaxis, and hexosemonophosphate-shunt response.

    • Main Results:

    • A transient monocytopenia was observed during the initial hours of therapy.
    • Monocyte killing of Staphylococcus aureus and Candida tropicalis was significantly reduced (p < 0.01).
    • Bactericidal activity normalized 48 hours post-therapy, while other functions like phagocytosis and chemotaxis remained normal or increased.

    Conclusions:

    • High-dose prednisone therapy transiently impairs the bactericidal and fungicidal capacity of human monocytes.
    • This functional impairment may contribute to the increased susceptibility to infections observed in patients on corticosteroid therapy.
    • Immune recovery occurs within 48 hours after cessation of short-term, high-dose prednisone treatment.