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Cutaneous innervation in hereditary sensory and autonomic neuropathy type IV
L Verzé1, C Viglietti-Panzica, L Plumari
1Laboratory of Neuroendocrinology, Department of Anatomy, Pharmacology and Forensic Medicine, University of Torino, Italy. laura.verze@unito.it
Abstract:
The authors investigated immunocytochemically the innervation of a skin biopsy in a rare case of hereditary sensory and autonomic neuropathy type IV. A few protein gene product 9.5-, growth-associated protein 43-, calcitonin gene-related peptide-, and substance P-immunoreactive nerve fibers were observed in the deeper regions of the dermis. Neuropeptide Y-, nitric oxide-, and vasoactive intestinal polypeptide-immunoreactive fibers were completely absent. Their observations support the hypothesis that the sensory and autonomic defects reported in hereditary sensory and autonomic neuropathy are based on profound developmental alterations of the peripheral nervous system.